Gender-specific Colorectal Cancer: Epidemiologic Difference and Role of Estrogen / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 201-208, 2014.
Article
Dans Coréen
| WPRIM
| ID: wpr-192823
ABSTRACT
Gender difference in the incidence of colorectal cancer is well known and has been supported by various epidemiologic studies. In Korea, women have lower incidence of colorectal cancer and adenoma, and the incidence in men has recently increased. Hormone replacement therapy in menopausal women is preventive of colorectal cancer but can cause cardiovascular diseases and breast cancer. Estrogen exerts diverse effects through estrogen receptors, ERalpha and ERbeta. ERbeta is associated with anti-proliferation and apoptosis. The ratio of ERalpha/ERbeta is important in the protection and tumorigenesis of colorectal cancer. Therefore ERbeta modulation has been investigated for preventing or treating colorectal cancer and avoiding adverse effects of estrogen at the same time. In addition, the gender-difference in the incidence of colorectal cancer should be taken into account when making guidelines on colorectal surveillance for Korean population.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs colorectales
/
Adénomes
/
Facteurs sexuels
/
Récepteur alpha des oestrogènes
/
Récepteur bêta des oestrogènes
/
Oestradiol dehydrogenases
/
Oestrogènes
Type d'étude:
Guide de pratique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
The Korean Journal of Gastroenterology
Année:
2014
Type:
Article
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