Prostate Cancer in a Patient with a Family History of BRCA Mutation: a Case Report and Literature Review
Journal of Korean Medical Science
;
: 377-381, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-193546
ABSTRACT
One of the most significant risk factors for prostate cancer (PC) is a family history of the disease, with germ-line mutations in the breast cancer predisposition gene (BRCA) 2 conferring the highest risk. We here report a 56-year-old man presented with painful gait disturbance and diagnosed PC with multiple disseminated bone metastases. The patient had a strong family history of breast cancer with his 2 nieces affected. Furthermore, his aunts and uncles from both sides were diagnosed with stomach, ovarian, and colorectal cancers. His genomic sequencing analysis of the BRCA genes revealed the same BRCA2 deleterious mutation that his breast cancer-affected nieces carried. Previous studies have suggested that BRCA2-mutated PC is associated with a more aggressive phenotype and poor prognosis. Our experience in the present case also indicated the urgent needs for novel treatment modality and PC screening in this high-risk group of patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Pronostic
/
Prostate
/
Tumeurs de la prostate
/
Estomac
/
Région mammaire
/
Tumeurs du sein
/
Tumeurs colorectales
/
Dépistage de masse
/
Facteurs de risque
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2017
Type:
Article
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