Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation
Endocrinology and Metabolism
;
: 11-17, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-194437
ABSTRACT
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs de transcription
/
Biodisponibilité
/
Expression des gènes
/
Régions promotrices (génétique)
/
Protéines de liaison aux IGF
/
Protéine-2 de liaison aux IGF
/
Isoformes de protéines
/
Foie
/
Maladies métaboliques
/
Obésité
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Endocrinology and Metabolism
Année:
2017
Type:
Article
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