Efficacy and safety of drospirenone 2 mg/17β-estradiol 1 mg hormone therapy in Korean postmenopausal women
Obstetrics & Gynecology Science
; : 213-217, 2017.
Article
de En
| WPRIM
| ID: wpr-194734
Bibliothèque responsable:
WPRO
ABSTRACT
This regulatory post-marketing surveillance study aimed to evaluate the therapeutic efficacy and safety of drospirenone (DRSP) 2 mg/estradiol (E₂) 1 mg tablet in Korean postmenopausal women. A total of 4,149 patients were enrolled and the study was conducted at 207 clinical research centers. The patients' source data was collected between November 2006 and November 2012. More than 85% of patients experienced improvement of menopausal symptoms. The most frequently reported adverse events were vaginal bleeding and breast pain; most of the women suffering from these symptoms fully recovered. The incidence of adverse event was higher in patients of younger age (20 to 39 years), in patients with concomitant diseases, previous hormone replacement therapy in medical history, those treated with DRSP 2 mg/E₂ 1 mg for shorter duration (3 years or less) and in patients using concomitant medication. In conclusion, the results from this large post-marketing surveillance study confirm the efficacy and safety of DRSP 2 mg/E₂ 1 mg tablet in Korean postmenopausal women.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Hémorragie utérine
/
Ménopause
/
Incidence
/
Hormonothérapie substitutive
/
Mastodynie
Type d'étude:
Incidence_studies
/
Prognostic_studies
Limites du sujet:
Female
/
Humans
langue:
En
Texte intégral:
Obstetrics & Gynecology Science
Année:
2017
Type:
Article