Manganese-Enhanced Magnetic Resonance Imaging of the Spinal Cord in Rats
Experimental Neurobiology
;
: 57-61, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-196702
ABSTRACT
Manganese-enhanced magnetic resonance imaging (MEMRI) offers a novel neuroimaging method in visualizing the activity patterns of neural circuits. MEMRI is using the divalent manganese ion, which has been used as a cellular contrast agent. The present study was conducted to determine the contrast-enhancing effects of manganese ion administered into the spinal cord of rats. Manganese ion was administered into the spinal cord by lumbar puncture. Ex vivo magnetic resonance images were obtained at 6, 12, 24, and 48 hours after manganese ion injection. Although the highly contrasted images were not observed 6 or 12 hr after manganese injection, the distinctive manganese-enhanced images began to appear at 24 hours after manganese ion injection. These results suggest that the gray matter is the foci of intense paramagnetic signals and MEMRI may provide an effective technique to visualize the activity-dependent patterns in the spinal cord.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Moelle spinale
/
Ponction lombaire
/
Imagerie par résonance magnétique
/
Spectroscopie par résonance magnétique
/
Neuroimagerie
/
Aimants
/
Magnétisme
/
Manganèse
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Experimental Neurobiology
Année:
2009
Type:
Article
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