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Successful desensitization for cytarabine induced anaphylaxis
Allergy, Asthma & Respiratory Disease ; : 394-397, 2014.
Article Dans Coréen | WPRIM | ID: wpr-197342
ABSTRACT
Cytarabine is a very important chemotherapeutic agent for leukemia and lymphoma patients and is prescribed more frequently than before. Cytarabine-induced delayed-onset hypersensitivity may rarely present as non-IgE mediated anaphylaxis. However, we do not know yet whether desensitization therapy in adults may be effective in cytarabine-induced delayed-onset anaphylaxis. A 78-year-old woman who was diagnosed with acute myeloblastic leukemia had chemotherapy including cytarabine. In spite of premedication with hydrocortisone and chlorpheniramine, the patient had anaphylaxis a few hours after cytarabine infusion. We decided to perform desensitization therapy. After desensitization therapy using a newly designed protocol, the patient was tolerable to cytarabine infusion without hypotension or high fever. Desensitization therapy was successfully performed on an adult patient with delayed-onset anaphylaxis caused by cytarabine.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Prémédication / Hydrocortisone / Leucémie aigüe myéloïde / Leucémies / Chlorphénamine / Désensibilisation immunologique / Cytarabine / Traitement médicamenteux / Fièvre / Hypersensibilité Type d'étude: Guide de pratique Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains langue: Coréen Texte intégral: Allergy, Asthma & Respiratory Disease Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Prémédication / Hydrocortisone / Leucémie aigüe myéloïde / Leucémies / Chlorphénamine / Désensibilisation immunologique / Cytarabine / Traitement médicamenteux / Fièvre / Hypersensibilité Type d'étude: Guide de pratique Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains langue: Coréen Texte intégral: Allergy, Asthma & Respiratory Disease Année: 2014 Type: Article