Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses
Experimental & Molecular Medicine
;
: 509-517, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-197471
ABSTRACT
4-1BB, a transmembrane molecule, member of the tumor necrosis factor receptor superfamily, is an important costimulatory molecule in the immune response, plays a key role in the clonal expansion and survival of CD8(+)T cells. In this study, we investigated 4-1BB regulation of CD4(+)T cell responses using 4-1BB transgenic (TG) mice that constitutively expressed 4-1BB on mature T cells. We first showed that CD4(+)T cells of 4-1BB TG mice had more sustained proliferative capacity in response to TCR/4-1BB stimulation in vitro compared to WT mice. Secondly, 4-1BB TG mice exhibited a more elevated contact hypersensitivity (CHS) response mediated by CD4+ Th1 cells due to more vigorous expansion of and apoptotic inhibition of CD4(+)T cells. Finally, CD4(+)T cells of 4-1BB TG mice had a heightened capacity for T cell priming. Overall, our results demonstrate the involvement of 4-1BB in CD4(+)Th1 cell responses by regulating the clonal expansion and survival of CD4(+)T cells as seen in CD8(+)T cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Souris transgéniques
/
Lymphocytes T CD4/
/
Antigènes CD
/
Expression des gènes
/
Division cellulaire
/
Récepteurs facteur croissance nerf
/
Récepteurs aux facteurs de nécrose tumorale
/
Lignage cellulaire
/
Eczéma de contact
/
Antigènes CD137
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2003
Type:
Article
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