An appraisal of pancreatic cyst fluid molecular markers
Gastrointestinal Intervention
;
: 32-36, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-198948
ABSTRACT
Pancreatic malignancy is the third leading cause of cancer related death in the United States with limited viable screening options. By the end of this decade, cancers are poised to become the leading cause of death with pancreatic cancer projected to be the second leading cause of cancer related mortality. Pancreatic cystic lesions (PCLs) are found in approximately 5%–14% of patients due to the increased utilization of cross-sectional imaging, with approximately 8%–10% of pancreatic cancers originating as PCLs. Current screening guidelines have shown discrepancies between morphologic characteristics of PCLs and identifying advanced pancreatic disease. Molecular analysis has emerged as a novel technology to aid in adequate diagnosis and management decisions of PCLs. Mucinous cysts including intraductal papillary mucinous neoplasms (IPMNs) or mucinous cystic neoplasms have similar oncogenic mutations including KRAS, TP53, SMAD4, PIK3CA, PTEN, or CKDN2A, while GNAS and RNF43 mutations are specific only to IPMNs. Serous cystadenomas have been associated with a loss of tumor suppressor gene VHL, while solid-psuedopapillary neoplasms have an oncogenic mutation CTNNB1. A specific molecular marker to diagnose existing high-grade dysplasia or impending malignant transformation is yet to be identified. Moving forward it is important to advance technology in isolating and identifying high-risk molecular markers from cyst fluid while considering their increased utilization in the evaluation of PCLs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Kyste du pancréas
/
Maladies du pancréas
/
Tumeurs du pancréas
/
États-Unis
/
Marqueurs biologiques tumoraux
/
Dépistage de masse
/
Mortalité
/
Cause de décès
/
Gènes suppresseurs de tumeur
/
Tumeurs kystiques, mucineuses et séreuses
Type d'étude:
Etude diagnostique
/
Guide de pratique
/
Étude pronostique
/
Étude de dépistage
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Nord
langue:
Anglais
Texte intégral:
Gastrointestinal Intervention
Année:
2017
Type:
Article
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