Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children / 소아과

ABSTRACT

PURPOSE: We studied the changes in antibiotic sensitivity to the causative organisms of urinary tract infection (UTI), in order to provide useful information on the choice of adequate drugs in the treatment of UTI. METHODS: We retrospectively analyzed the major causative organisms and their antibiotic sensitivities in 69 patients diagnosed with UTI in the Department of Pediatrics, Samsung Cheil Hospital from 2002 to 2003. RESULTS: The frequency of UTI was the highest in infants younger than 1 year of age (88.4 percent). The male to female ratio was 3.05: 1. Escherichia coli was the most frequent organism (78.3 percent), followed by Klebsiella (116 percent), Pseudomonas (2.9 percent), Proteus (2.9 percent), Enterobacter, Morganelle, and Enterococcus (1.4 percent) in descending order. Antibiotic sensitivity of gram negative organisms was above 90 percent against imipenem, amikacin, 80 percent against aztreonam, cefepime, ceftriaxone, 50-70 percent against gentamicin, trimethoprime-sulfamethoxazole (TMP/SMX), and 23 percent against ampicillin (23.4 percent). CONCLUSION: Antibiotict sensitivity of gram negative organisms was high to amikacin and third generation cephalosporins but low to ampicillin, gentamicin and TMP/SMX. The use of ampicillin or TMP/SMX, as the first choice of the empiric and prophylactic treatment for UTI, should be reconsidered and investigated further.