The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Intrathecal Zaprinast in the Formalin Test of Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 85-90, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-200356
ABSTRACT
BACKGROUND:
Spinal zaprinast, phospodiesterase inhibitor, has been shown to have an antinociception through an increase of cGMP. The aim of this study was to examine the role of spinal adrenergic and cholinergic receptors on the antinociceptive action of intrathecal zaprinast.METHODS:
Rats were implanted with lumbar intrathecal catheters. After formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min. After observing the effect of intrathecal zaprinast, antagonism of intrathecal prazosin, yohimbine, atropine and mecamylamine for the effect of zaprinast were evaluated.RESULTS:
Intrathecal zaprinast produced a dose-dependent suppression of formalin-induced flinches in both phases of the formalin test. Intrathecal prazosin reversed the antinociception of zaprinast in phase 2, but not phase 1. Intrathecal yohimbine reversed the antinociception of zaprinast in both phases. Neither atropine nor mecamylamine reversed the antinocicetive action of zaprinast.CONCLUSIONS:
Intrathecal zaprinast is against the nociceptive state evoked by formalin stimulus. Alpha 2 or alpha 1 adrenergic receptor, but not cholinergic receptors, may be related to the action of zaprinast in the spinal cord.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Atropine
/
Moelle spinale
/
Yohimbine
/
Mesure de la douleur
/
Prazosine
/
Récepteurs cholinergiques
/
Récepteurs alpha-1 adrénergiques
/
Cathéters
/
Formaldéhyde
/
Mécamylamine
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Anesthesiology
Année:
2007
Type:
Article
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