The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model
Immune Network
;
: 291-295, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-20062
ABSTRACT
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-alpha. The fraction also increased the production of TGF-beta and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-alpha, as well as secretion of VEGF, TGF-beta and HS may have a new bioactive material for the treatment of skin wound.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sperme
/
Peau
/
Ulcère
/
Cicatrisation de plaie
/
Cytokines
/
Facteur de croissance transformant bêta
/
Facteur de nécrose tumorale alpha
/
Pied diabétique
/
Facteur de croissance endothéliale vasculaire de type A
/
Acides gras
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Immune Network
Année:
2012
Type:
Article
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