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The Relationship between Serum Adiponectin, Essential Hypertension, LV Mass Index, and LV Diastolic Function
Korean Circulation Journal ; : 1126-1133, 2003.
Article Dans Coréen | WPRIM | ID: wpr-202132
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Adiponectin is known for its anti-inflammatory and anti-atherogenic effects. The purpose of this study is to characterize the relationships among serum adiponectin, essential hypertension (EH), left ventricular mass index (LVMI), and LV diastolic function. SUBJECTS AND

METHODS:

Serum adiponectin by RIA and body mass index were measured in 275 patients (M F=137 138). We calculated LVMI, E/A ratio, deceleration time (DT), and isovolumetric relaxation time (IVRT) by using echocardiograms.

RESULTS:

The serum adiponectin level of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9+/-9.8 ug/mL vs. 12.9+/-9.5 ug/mL, p<0.05). Plasma adiponectin was negatively correlated with LVMI (r=-0.329, p<0.001), BMI (r=-0.290, p<0.001), and IVRT (r=-0.485, p<0.05), but was positively correlated with E/A (r=+0.359, p<0.001).

CONCLUSION:

These results suggest that a decrease in serum adiponectin is associated with an increase in blood pressure and BMI, progress of LVH, and decrease in LV diastolic function.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Plasma sanguin / Relaxation / Pression sanguine / Indice de masse corporelle / Hypertrophie ventriculaire gauche / Décélération / Adiponectine / Hypertension artérielle Limites du sujet: Humains langue: Coréen Texte intégral: Korean Circulation Journal Année: 2003 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Plasma sanguin / Relaxation / Pression sanguine / Indice de masse corporelle / Hypertrophie ventriculaire gauche / Décélération / Adiponectine / Hypertension artérielle Limites du sujet: Humains langue: Coréen Texte intégral: Korean Circulation Journal Année: 2003 Type: Article