Fertility sparing surgery in early stage epithelial ovarian cancer / 부인종양
Journal of Gynecologic Oncology
;
: 320-327, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-202218
ABSTRACT
OBJECTIVE:
Fertility sparing surgery (FSS) is a strategy often considered in young patients with early epithelial ovarian cancer. We investigated the role and the outcomes of FSS in eEOC patients who underwent comprehensive surgery.METHODS:
From January 2003 to January 2011, 24 patients underwent fertility sparing surgery. Eighteen were one-to-one matched and balanced for stage, histologic type and grading with a group of patients who underwent radical comprehensive staging (n=18). Demographics, surgical procedures, morbidities, pathologic findings, recurrence-rate, pregnancy-rate and correlations with disease-free survival were assessed.RESULTS:
A total of 36 patients had a complete surgical staging including lymphadenectomy and were therefore analyzed. Seven patients experienced a recurrence four (22%) in the fertility sparing surgery group and three (16%) in the control group (p=not significant). Sites of recurrence were residual ovary (two), abdominal wall and peritoneal carcinomatosis in the fertility sparing surgery group; pelvic (two) and abdominal wall in the control group. Recurrences in the fertility sparing surgery group appeared earlier (mean, 10.3 months) than in radical comprehensive staging group (mean, 53.3 months) p<0.001. Disease-free survival were comparable between the two groups (p=0.422). No deaths were reported. All the patients in fertility sparing surgery group recovered a regular period. Thirteen out of 18 (72.2%) attempted to have a pregnancy. Five (38%) achieved a spontaneous pregnancy with a full term delivery.CONCLUSION:
Fertility sparing surgery in early epithelial ovarian cancer submitted to a comprehensive surgical staging could be considered safe with oncological results comparable to radical surgery group.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'ovaire
/
Issue de la grossesse
/
Analyse de survie
/
Études rétrospectives
/
Résultat thérapeutique
/
Tumeurs épithéliales épidermoïdes et glandulaires
/
Fécondité
/
Préservation de la fertilité
/
Infertilité féminine
/
Lymphadénectomie
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Grossesse
langue:
Anglais
Texte intégral:
Journal of Gynecologic Oncology
Année:
2014
Type:
Article
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