A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
Journal of Korean Medical Science
;
: 959-961, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-202308
ABSTRACT
The incidence of pulmonary embolism (PE) rises markedly with age, and only a few cases have been reported in younger adults. Thrombophilia has been reported as one of the predisposing factors for PE in younger adults. Here we report an extraordinary case of PE complicated with dysplasminogenemia, a rare genetic disorder resulting in hypercoagulability, in a young male. An 18-yr-old male visited an emergency room in the United States complaining chest discomfort. He was diagnosed as PE with deep vein thrombosis without apparent risk factors. Anticoagulation therapy with warfarin had been initiated and discontinued after 6 months of treatment. After returning to Korea he was tested for thrombophilia which revealed decreased activity of plasminogen and subsequent analysis of PLG gene showed heterozygous Ala620Thr mutation. He was diagnosed with PE complicated with dysplasminogenemia. Life-long anticoagulation therapy was initiated. He is currently under follow-up without clinical events for 2 yr.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasminogène
/
Embolie pulmonaire
/
Maladies génétiques de la peau
/
Warfarine
/
Tomodensitométrie
/
Maladie aigüe
/
Facteurs de risque
/
Conjonctivite
/
Thrombose veineuse
/
Polymorphisme de nucléotide simple
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2013
Type:
Article
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