Protective Effect of Fisetin (3,7,3',4'-Tetrahydroxyflavone) against gamma-Irradiation-Induced Oxidative Stress and Cell Damage
Biomolecules & Therapeutics
;
: 210-215, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-202362
ABSTRACT
Ionizing radiation can induce cellular oxidative stress through the generation of reactive oxygen species, resulting in cell damage and cell death. The aim of this study was to determine whether the antioxidant effects of the flavonoid fisetin (3,7,3',4'-tetrahydroxyflavone) included the radioprotection of cells exposed to gamma-irradiation. Fisetin reduced the levels of intracellular reactive oxygen species generated by gamma-irradiation and thereby protected cells against gamma-irradiation-induced membrane lipid peroxidation, DNA damage, and protein carbonylation. In addition, fisetin maintained the viability of irradiated cells by partially inhibiting gamma-irradiation-induced apoptosis and restoring mitochondrial membrane potential. These effects suggest that the cellular protective effects of fisetin against gamma-irradiation are mainly due to its inhibition of reactive oxygen species generation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rayonnement ionisant
/
Altération de l'ADN
/
Peroxydation lipidique
/
Mort cellulaire
/
Espèces réactives de l'oxygène
/
Apoptose
/
Stress oxydatif
/
Carbonylation des protéines
/
Potentiel de membrane mitochondriale
/
Membranes
langue:
Anglais
Texte intégral:
Biomolecules & Therapeutics
Année:
2013
Type:
Article
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