Elevated red cell distribution width is associated with advanced fibrosis in NAFLD
Clinical and Molecular Hepatology
;
: 258-265, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-202391
ABSTRACT
BACKGROUND/AIMS:
The red-blood-cell distribution width (RDW) is a newly recognized risk marker in patients with cardiovascular disease, but its role in nonalcoholic fatty liver disease (NAFLD) has not been well defined. The aim of the present study was to determine the association between RDW values and the level of fibrosis in NAFLD according to BARD and FIB-4 scores.METHODS:
This study included 24,547 subjects who had been diagnosed with NAFLD based on abdominal ultrasonography and questionnaires about alcohol consumption. The degree of liver fibrosis was determined according to BARD and FIB-4 scores. The association between RDW values and the degree of fibrosis in NAFLD was analyzed retrospectively.RESULTS:
After adjusting for age, hemoglobin level, mean corpuscular volume, history of hypertension, history of diabetes, and high-sensitivity C-reactive protein, the RDW values were 12.61+/-0.41% (mean+/-SD), 12.70+/-0.70%, 12.77+/-0.62%, 12.87+/-0.82%, and 13.25+/-0.90% for those with BARD scores of 0, 1, 2, 3, and 4, respectively, and 12.71+/-0.72%, 12.79+/-0.66%, and 13.23+/-1.52% for those with FIB-4 scores of or =2.67, respectively (P or =1.3) increased with the RDW [BARD score 51.1% in quartile 1 (Q1) vs. 63.6% in Q4; FIB-4 score 6.9% in Q1 vs. 10.5% in Q4; P<0.001]. After adjustments, the odds ratio of having advanced fibrosis for those in Q4 compared to Q1 were 1.76 (95%CI=1.55-2.00, P<0.001) relative to BARD score and 1.69 (95%CI=1.52-1.98, P<0.001) relative to FIB-4 score.CONCLUSIONS:
Elevated RDW is independently associated with advanced fibrosis in NAFLD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Indice de gravité de la maladie
/
Consommation d'alcool
/
Protéine C-réactive
/
Odds ratio
/
Prévalence
/
Enquêtes et questionnaires
/
Diabète
/
Index érythrocytaires
/
Stéatose hépatique
/
Hypertension artérielle
Type d'étude:
Etude d'étiologie
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinical and Molecular Hepatology
Année:
2013
Type:
Article
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