HCV Serotypes and HCV RNA Quantitation / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 259-264, 1998.
Article
Dans Coréen
| WPRIM
| ID: wpr-202975
ABSTRACT
BACKGROUND:
There are several serological subtypes (serotypes) of hepatitis C virus (HCV) which can be detected by a serological enzyme immunoassay (EIA) method which detects the HCV subtype-specific antibodies against the NS4 region of the virus. We determined the HCV serotypes chronic HCV infected patients in terms of clinical applications.METHODS:
Subtypes based on Simmonds' classification were detected in chronic HCV patients serologically and viral loads quantitated with branched DNA (bDNA) assay. The EIA was compared with multiplex PCR method.RESULTS:
The serotype 1 (Simmonds' classification, 1a, 1b, 1c), the most prevalent form in Korea followed by serotype 2 (Simmonds' classification, 2a, 2b, 2c). The distribution of serotypes and HCV viral loads were not different according to disease severity. The patients infected with serotype 1 had higher viremic level (serotype 1, 7.4+/-15.5 MEq/mL; serotype 2, 1.1+/-2.2 MEq/mL, P=0.017). The serotype matched with the genotype in 85.7% (18/21) of cases.CONCLUSIONS:
HCV serotype 1 is the most prevalent form in Korea and seemed to be able to more actively replicate than serotype 2. Both multiplex PCR and EIA can be used for detecting HCV subtypes and mutually interpretable.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
ADN
/
ARN
/
Techniques immunoenzymatiques
/
Classification
/
Hepacivirus
/
Charge virale
/
Réaction de polymérisation en chaine multiplex
/
Génotype
/
Corée
/
Anticorps
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Korean Journal of Clinical Pathology
Année:
1998
Type:
Article
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