A Case of Solitary Indeterminate Cell Histiocytoma / 대한피부과학회지

ABSTRACT

Indeterminate cell histiocytosis is a vary rare disease characterized by the proliferation of indeterminate histiocytes which morphologically and immunophenotypically resemble Langerhans cell but lack Birbeck granules. We report a case of solitary indeterminate cell histiocytoma in a 58-year-old woman. She presented with painless and nonprurituc solitary brownish papule on the left wrist, which had developed 10 years earlier. Histologic and immunohistochemical examination of the biopsy revealed a diffuse dermal infiltrate composed mainly of histiocytes which expressed Langerhans cell marker characteristics. Electron microscopic studies revealed no Birbeck granules within cytoplasm of the neoplastic cells, leading to a diagnosis of indeterminate cell histiocytosis.