Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 52-57, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-203236
ABSTRACT
PURPOSE:
To obtain basic data for development of a glioblastoma-specific immunotoxin, the expression of variable cell surface receptors on a human glioblastoma xenograft model was evaluated, using NOD/SCID mice. MATERIALS ANDMETHODS:
We developed a xenograft model in NOD/SCID mice implanted with a human glioblastoma cell line (U-87MG). Immunohistochemical studies were performed on implanted tumor nodules (n=8) using antibodies against CD71, EGFR, IGF-IRalpha, CXCR4 and IL-4Ralpha.RESULTS:
Expression of IL-4Ralpha, in implanted tumornodules, was the highest of the cell surface receptors evaluated in this study. However, the endothelial cells in, and around, the tumor nodules also revealed immunopositivity against IL-4Ralpha. The immunoreactivity of IL-4Ralpha, and other surface receptors such as CD71, IGF-IRalpha and EGFR, was prominent in tumor nodules associated with tumor necrosis.CONCLUSION:
IL-4Ralpha would be a possible target for the development of glioblastoma-specific immunotoxin, although there are limitations due to its endothelial expression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Lignée cellulaire
/
Immunotoxines
/
Souris SCID
/
Glioblastome
/
Récepteurs de surface cellulaire
/
Cellules endothéliales
/
Hétérogreffes
/
Anticorps
/
Nécrose
Limites du sujet:
Animaux
/
Humains
langue:
Coréen
Texte intégral:
Cancer Research and Treatment
Année:
2002
Type:
Article
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