New COX-2 Inhibitors / 대한내과학회지
Korean Journal of Medicine
; : 250-256, 2016.
Article
de Ko
| WPRIM
| ID: wpr-20338
Bibliothèque responsable:
WPRO
ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation. There are two kinds of NSAID classified according to the selectivity of COX-2 inhibition: non-selective NSAIDs and cyclooxygenase (COX)-2 inhibitors. Non-selective NSAIDs have a high incidence of gastrointestinal and bleeding-associated adverse events, while COX-2 inhibitors are safer in terms of these events. However, COX-2 inhibitors are thought to cause increased cardiovascular events. The COX-2 inhibitors rofecoxib and valdecoxib were withdrawn from the market over safety concerns. Three COX-2 inhibitors are now available in South Korea after the recent approval of etoricoxib and polmacoxib for osteoarthritis patients. After reviewing the history of and recent studies about the safety of COX-2 inhibitors, physicians should find new uses for old drugs.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Arthrose
/
Anti-inflammatoires non stéroïdiens
/
Incidence
/
Inhibiteurs des cyclooxygénases
/
Prostaglandin-endoperoxide synthases
/
Inhibiteurs de la cyclooxygénase 2
/
Inflammation
/
Corée
Type d'étude:
Incidence_studies
/
Prognostic_studies
Limites du sujet:
Humans
Pays comme sujet:
Asia
langue:
Ko
Texte intégral:
Korean Journal of Medicine
Année:
2016
Type:
Article