SERPINE2 Polymorphisms and Chronic Obstructive Pulmonary Disease
Journal of Korean Medical Science
;
: 1119-1125, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-203380
ABSTRACT
A number of genome-wide linkage analyses have identified the 2q33.3-2q37.2 region as most likely to contain the genes that contribute to the susceptibility to chronic obstructive pulmonary disease (COPD). It was hypothesized that the SERPINE2 gene, which is one of the genes located at the 2q33.3-2q37.2 region, may act as a low-penetrance susceptibility gene for COPD. To test this hypothesis, the association of four SERPINE2 single nucleotide polymorphisms (SNPs; rs16865421A>G, rs7583463A>C, rs729631C>G, and rs6734100C>G) with the risk of COPD was investigated in a case-control study of 311 COPD patients and 386 controls. The SNP rs16865421 was associated with a significantly decreased risk of COPD in a dominant model for the polymorphic allele (adjusted odds ratio [OR]=0.66, 95% confidence interval [CI]=0.45-0.97, P=0.03). In haplotype analysis, the GACC haplotype carrying the polymorphic allele at the rs16865421 was associated with a significantly decreased risk of COPD when compared to the AACC haplotype (adjusted OR=0.58, 95% CI=0.38-0.89, P=0.01), and this effect was evident in younger individuals (adjusted OR=0.30, 95% CI=0.14-0.64, P=0.002). This study suggests that the SERPINE2 gene contributes to the susceptibility to COPD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Haplotypes
/
Enquêtes et questionnaires
/
Précurseur de la protéine bêta-amyloïde
/
Récepteurs de surface cellulaire
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Broncho-pneumopathie chronique obstructive
/
Étude d'association pangénomique
/
Génotype
/
Liaison génétique
Type d'étude:
Étude observationnelle
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2009
Type:
Article
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