Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy / 대한신장학회잡지
Korean Journal of Nephrology
;
: 26-31, 2005.
Article
Dans Coréen
| WPRIM
| ID: wpr-203780
ABSTRACT
PURPOSE:
Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy.METHODS:
Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2 mg/kg). After 6 weeks, rats showing heavy proteinuria were orally treated with either cilazapril 1 mg/kg/day (ACEi group, n=7) or losartan 10 mg/kg/day (ARB group, n=7) during the period of additional 6 weeks. The other group was maintained without any drugs (ADR group, n=6). The control group was without adriamycin treatment and maintained during the 12 weeks (Control, n=5).RESULTS:
Systolic blood pressure was increased following the adriamycin treatment, which was normalized by treatment with cilazapril or losartan. Accordingly, cilazapril and losartan normalized the 24-h urine protein/creatinine ratio, in association with morphologic improvement of tubulointerstitial lesions. The expression of laminin beta1 was not altered in any experimental groups.CONCLUSION:
These results suggest that angiotensin II plays an important role in tubulointerstitial lesions in adriamycin-induced nephropathy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéinurie
/
Système rénine-angiotensine
/
Pression sanguine
/
Angiotensine-II
/
Doxorubicine
/
Laminine
/
Rat Sprague-Dawley
/
Cilazapril
/
Losartan
Limites du sujet:
Animaux
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Korean Journal of Nephrology
Année:
2005
Type:
Article
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