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Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy / 대한신장학회잡지
Korean Journal of Nephrology ; : 26-31, 2005.
Article Dans Coréen | WPRIM | ID: wpr-203780
ABSTRACT

PURPOSE:

Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy.

METHODS:

Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2 mg/kg). After 6 weeks, rats showing heavy proteinuria were orally treated with either cilazapril 1 mg/kg/day (ACEi group, n=7) or losartan 10 mg/kg/day (ARB group, n=7) during the period of additional 6 weeks. The other group was maintained without any drugs (ADR group, n=6). The control group was without adriamycin treatment and maintained during the 12 weeks (Control, n=5).

RESULTS:

Systolic blood pressure was increased following the adriamycin treatment, which was normalized by treatment with cilazapril or losartan. Accordingly, cilazapril and losartan normalized the 24-h urine protein/creatinine ratio, in association with morphologic improvement of tubulointerstitial lesions. The expression of laminin beta1 was not altered in any experimental groups.

CONCLUSION:

These results suggest that angiotensin II plays an important role in tubulointerstitial lesions in adriamycin-induced nephropathy.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Protéinurie / Système rénine-angiotensine / Pression sanguine / Angiotensine-II / Doxorubicine / Laminine / Rat Sprague-Dawley / Cilazapril / Losartan Limites du sujet: Animaux / Humains / Mâle langue: Coréen Texte intégral: Korean Journal of Nephrology Année: 2005 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Protéinurie / Système rénine-angiotensine / Pression sanguine / Angiotensine-II / Doxorubicine / Laminine / Rat Sprague-Dawley / Cilazapril / Losartan Limites du sujet: Animaux / Humains / Mâle langue: Coréen Texte intégral: Korean Journal of Nephrology Année: 2005 Type: Article