Effects of anti-allergic drugs on intestinal mastocytosis and worm expulsion of rats infected with Neodiplostomum seoulense
The Korean Journal of Parasitology
;
: 81-87, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-206125
ABSTRACT
The effects of anti-allergic drugs on intestinal mastocytosis and the expulsion of Neodiplostomum seoulense were observed in Sprague-Dawley rats, after oral infection with 500 metacercariae. The drugs used were hydroxyzine (a histamine receptor H1 blocker), cimetidine (a H2 blocker), cyclosporin-A (a helper T-cell suppressant), and prednisolone (a T- and B-cell suppressant). Infected, but untreated controls, and uninfected controls, were prepared. Worm recovery rate and intestinal mastocytosis were measured on weeks 1, 2, 3, 5, and 7 post-infection. Compared with the infected controls, worm expulsion was significantly (P < 0.05) delayed in hydroxyzine- and cimetidine-treated rats, despite mastocytosis being equally marked in the duodenum of all three groups. In the cyclosporin-A- and prednisolone-treated groups, mastocytosis was suppressed, but worm expulsion was only slightly delayed, without statistical significance. Our results suggest that binding of histamine to its receptors on intestinal smooth muscles is more important in terms of the expulsion of N. seoulense from rats than the levels of histamine alone, or mastocytosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Trematoda
/
Infections à trématodes
/
Mastocytose
/
Prednisolone
/
Cimétidine
/
Ciclosporine
/
Rat Sprague-Dawley
/
Antihistaminiques des récepteurs H1
/
Antihistaminiques des récepteurs H2
/
Hydroxyzine
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
The Korean Journal of Parasitology
Année:
2003
Type:
Article
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