Screening of Genes Regulating TNF-alpha-mediated Synovial Hyperplasia in Rheumatoid Arthritis / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 89-95, 2003.
Article
Dans Coréen
| WPRIM
| ID: wpr-208438
ABSTRACT
Chronic rheumatoid arthritis (RA) is characterized by the hyperplasia of synovial tissue, which results from the combined influence of the proliferation and antiapoptosis of the synovial cells. In this study, to identify candidate factors involved in the regulation of synovial hyperplasia, the expression profile of 205 apoptosis-related genes in a rheumatoid synovium was analyzed in comparison with that in an osteoarthritis (OA) synovium using a cDNA microarray. Upregulated genes in the RA synovium include TNFR2, GRB2, RBL2, CDC25B, MAPK p38, CDK-like kinase 2, and FLICE2, whereas 5 genes including SARP1 were down-regulated relative to OA. Among them, importantly, the expression levels of GRB2 and FLICE2 genes were remarkably enhanced in RA but not OA synoviocytes in response to TNF -alpha treatment. Therefore, TNF-alpha inducibility to GRB2 and FLICE2 genes abnormally enhanced in RA synoviocytes might represent the increased transcripts of these two genes in rheumatoid sunovial tissues. Moreover, these results suggest that RA-specific signals by TNF-alpha, including GRB2 and FLICE2, are involved in the pathogenic processes of synovial hyperplasia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Arthrose
/
Phosphotransferases
/
Polyarthrite rhumatoïde
/
Membrane synoviale
/
Dépistage de masse
/
Facteur de nécrose tumorale alpha
/
Séquençage par oligonucléotides en batterie
/
Récepteur au facteur de nécrose tumorale de type II
/
Hyperplasie
Type d'étude:
Etude diagnostique
/
Étude pronostique
/
Étude de dépistage
langue:
Coréen
Texte intégral:
Korean Journal of Physical Anthropology
Année:
2003
Type:
Article
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