Diagnostic and Therapeutic Strategies for Severe Alcoholic Hepatitis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 4-11, 2015.
Article
Dans Coréen
| WPRIM
| ID: wpr-208451
ABSTRACT
Alcoholic hepatitis (AH) is defined as an acute hepatic manifestation resulting from heavy alcohol intake. Histologically, alcoholic steatohepatitis (ASH) is characterized by hepatocellular steatosis, inflammation, and fibrosis. Alcohol abstinence is the sine qua non of therapy for AH and, in the milder forms, is prerequisite to clinical recovery. Severe ASH may lead to multi-organ failure such as acute kidney injury and infection, which has a major impact on survival and thus should be closely monitored. Patients with severe ASH have a drastic short-term mortality of up to 40-50%. Specific therapies should be considered for patients with severe ASH at risk of early death. Corticosteroids are the standard of care for patients with severe ASH. When corticosteroids are contraindicated, pentoxifylline may be an alternative option. Steroid responsiveness should be evaluated on the basis of Lille score. Tactically, we should explore novel therapeutic targets to suppress inflammation based on cytokine profiles, promote hepatic regeneration, limit innate immune responses, and restore altered gut mucosal integrity in severe ASH.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pentoxifylline
/
Pronostic
/
Indice de gravité de la maladie
/
Piégeurs de radicaux libres
/
Transplantation hépatique
/
Hormones corticosurrénaliennes
/
Hépatite alcoolique
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
The Korean Journal of Gastroenterology
Année:
2015
Type:
Article
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