Protective effects of mastic in non-steroidal anti-inflammatory drug induced gut damage and bacterial translocation in a rat model / 대한내과학회지
Korean Journal of Medicine
;
: 354-361, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-208851
ABSTRACT
BACKGROUND:
NSAIDs induce gut damage and bacterial translocation throughout the entire gastrointestinal tract. The aim of the present study was to examine whether mastic, a natural resinous exudate obtained from the Pistacia lentiscus treetrees, can reduce diclofenac induce gut damage and bacterial translocation in rats.METHODS:
32 SD rats were divided into four groups; a control group, diclofenac group, diclofenac with 0.3 cc/kg mastic group and diclofenac with 1.0 cc/kg mastic group. Mastic oils were administered 3 hours before diclofenac administration (100 mg/kg orally x2 days). Intestinal permeability, enteric aerobic bacterial counts in the distal ileum and cecum, intestinal adhesion, lipid peroxidation of distal ileum, and bacterial translocation to mesenteric lymph nodes, liver, spleen, kidney and heart were measured, respectivelyRESULTS:
Diclofenac caused marked increase in intestinal permeability, enteric bacterial numbers in distal ileum and cecum, intestinal adhesion, lipid peroxidation of the distal ileum, and bacterial translocation to mesenteric lymph nodes, liver, spleen, kidney and heart of which event were reduced with Mostic coadminist. Howere mastic oil showed significant profect effects in 1.0 cc/kg dose.CONCLUSIONS:
Mastic was proven to have beneficial effects on preventing NSAID induced gut injury and bacterial translocation in a rat model.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Perméabilité
/
Rate
/
Huiles
/
Peroxydation lipidique
/
Caecum
/
Anti-inflammatoires non stéroïdiens
/
Diclofenac
/
Translocation bactérienne
/
Modèles animaux
/
Pistacia
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
2006
Type:
Article
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