A Case of Propylthiouracil induced Antineutrophil Cytoplasmic Antibody Positive Pyoderma Gangrenosum

ABSTRACT

Pyoderma gangrenosum (PG) is a rare disease that causes chronic skin ulcers, and it has recently been known to be related to changes in the immune system such as dysfunction of neutrophils. Over 50% of patients with PG have an underlying systemic disease, and rarely are there various medicines causing the disease, including iodide, bromide, and isotretinoin. A 49-year-old man had recurrent skin ulcers in his lower extremities. He had a history of taking propylthiouracil (PTU) for 10 years as a treatment for Graves' disease. Here, we describe a case of PTU-induced ANCA positive PG in a patient with hyperthyroidism, who has been improved after the cessation of PTU.