Functional Regulation of Dopamine D₃ Receptor through Interaction with PICK1
Biomolecules & Therapeutics
;
: 475-481, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-209246
ABSTRACT
PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine D₃ receptors (D₃R), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine D₂ receptor (D₂R) and D₃R in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of D₂R were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of D₃R were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on D₃R functions.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Dopamine
/
Autorécepteurs
/
Endocytose
/
Transporteurs de la dopamine
/
Neurones dopaminergiques
/
Main
langue:
Anglais
Texte intégral:
Biomolecules & Therapeutics
Année:
2016
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS