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Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
Korean Journal of Veterinary Research ; : 117-120, 2016.
Article Dans Anglais | WPRIM | ID: wpr-20936
ABSTRACT
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Ostéoporose / Paralysie / Tibia / Auto-immunité / Densité osseuse / Encéphalomyélite auto-immune expérimentale / Membre pelvien / Inflammation Limites du sujet: Animaux langue: Anglais Texte intégral: Korean Journal of Veterinary Research Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Ostéoporose / Paralysie / Tibia / Auto-immunité / Densité osseuse / Encéphalomyélite auto-immune expérimentale / Membre pelvien / Inflammation Limites du sujet: Animaux langue: Anglais Texte intégral: Korean Journal of Veterinary Research Année: 2016 Type: Article