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Hair growth promoting effects of emodin in telogenic C57BL/6 mice
Korean Journal of Veterinary Research ; : 97-101, 2016.
Article Dans Anglais | WPRIM | ID: wpr-20940
ABSTRACT
Emodin is an anthraquinone derivative from the roots of Rheum officinale Baill that possesses a variety of biological activities, including inhibition of 5α-reductase and prostaglandin D2. In this study, we investigated whether emodin promotes hair growth. After emodin was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the hair growth rate and morphological analysis were evaluated in dorsal skin for 15 days. After 13 days of treatment, minoxidil or emodin (0.01% or 0.1%)-treated groups showed remarkable regrowth of hairs relative to the vehicle control group. Scoring of the hair growth and rate of hair growth area for 15 days revealed that groups treated with minoxidil and 0.1% emodin were significantly higher than the vehicle control group. Histological examination revealed the emodin and minoxidil groups markedly recovered the number and morphology of hair follicles, including the subcutis depth, relative to the vehicle group. These results suggest that emodin has an excellent promoting effect in hair growth similar to that of minoxidil and might be useful for treatment of baldness or alopecia.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Rheum / Peau / Prostaglandine D2 / Émodine / Follicule pileux / Alopécie / Poils / Minoxidil Limites du sujet: Animaux langue: Anglais Texte intégral: Korean Journal of Veterinary Research Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Rheum / Peau / Prostaglandine D2 / Émodine / Follicule pileux / Alopécie / Poils / Minoxidil Limites du sujet: Animaux langue: Anglais Texte intégral: Korean Journal of Veterinary Research Année: 2016 Type: Article