Effects of Chitosan on the Differentiation of MDPC-23 Cells
International Journal of Oral Biology
;
: 91-97, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-209528
ABSTRACT
The effects of chitosan upon the experimentally induced differentiation of MDPC-23 cells, derived from mouse dental papilla cells, were investigated by RT-PCR, observations of cell morphology and Alizaline red-S staining. Chitosan was found to significantly increase and accelerate the expression of ALP mRNA but decrease the ColI transcript levels, as compared with the control, in a time-dependent manner during the differentiation of MDPC-23 cells. Chitosan also significantly downregulated ON mRNA expression and accelerated mineralization in differentiating MDPC-23 cells. These results suggest that chitosan facilitates odontoblast differentiation and mineralization and may have potential clinical applications as a dentin regeneration material.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Régénération
/
ARN messager
/
Papille dentaire
/
Dentine
/
Chitosane
/
Odontoblastes
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
International Journal of Oral Biology
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS