Polymeric Gene Delivery for Diabetic Treatment
Diabetes & Metabolism Journal
;
: 317-326, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-210390
ABSTRACT
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasmides
/
Polyéthylène glycols
/
Polylysine
/
Polymères
/
ADN
/
ARN messager
/
Souris de lignée NOD
/
Interleukine-10
/
Transplants
/
Petit ARN interférent
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Diabetes & Metabolism Journal
Année:
2011
Type:
Article
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