Your browser doesn't support javascript.
loading
Temozolomide Chemotherapy in Patients with Recurrent Malignant Gliomas
Article de En | WPRIM | ID: wpr-211997
Bibliothèque responsable: WPRO
ABSTRACT
Numerous studies have demonstrated the clinical activity of temozolomide, a second-generation alkylating agent, against malignant brain tumors, however, its activity has not been reported in an Asian population. This study analyzed the efficacy and toxicity of temozolomide in 25 adult patients with recurrent or progressive malignant gliomas after surgery and standard radiation therapy with or without chemotherapy, enrolled in our institution since July 2000. Sixteen patients had glioblastoma multiforme (GBM), six with anaplastic astrocytoma, and three with anaplastic oligodendroglioma. Of the 25 patients, 3 (12%) achieved a complete response (CR), 8 (32%) achieved a partial response (PR), 6 (24%) had stable disease (SD), and 8 (32%) had progressive disease (PD). Two patients achieved a CR, 4 patients achieved a PR, 3 patients had SD and 7 patients had PD in GBM, and 1 patient achieved a CR, 4 patients achieved a PR, 3 patients had SD, 1 patient had PD in the non-GBM patients. Median progression free survival was 8 weeks in GBM and 22 weeks in the non-GBM patients. The median overall survival of each group was 17 weeks and 28 weeks. Temozolomide demonstrated moderate activity in recurrent and progressive malignant gliomas without serious toxicity.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Vomissement / Encéphale / Tumeurs du cerveau / Calendrier d'administration des médicaments / Imagerie par résonance magnétique / Analyse de survie / Administration par voie orale / Résultat thérapeutique / Association thérapeutique / Antinéoplasiques alcoylants Limites du sujet: Adolescent / Adult / Female / Humans / Male langue: En Texte intégral: Journal of Korean Medical Science Année: 2006 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Vomissement / Encéphale / Tumeurs du cerveau / Calendrier d'administration des médicaments / Imagerie par résonance magnétique / Analyse de survie / Administration par voie orale / Résultat thérapeutique / Association thérapeutique / Antinéoplasiques alcoylants Limites du sujet: Adolescent / Adult / Female / Humans / Male langue: En Texte intégral: Journal of Korean Medical Science Année: 2006 Type: Article