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The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
Journal of Korean Medical Science ; : 793-797, 2014.
Article Dans Anglais | WPRIM | ID: wpr-212024
ABSTRACT
Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tumeurs de l'ovaire / Indice de masse corporelle / Modèles des risques proportionnels / Études rétrospectives / Facteurs de risque / Tumeurs épithéliales épidermoïdes et glandulaires / Estimation de Kaplan-Meier / Stadification tumorale Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tumeurs de l'ovaire / Indice de masse corporelle / Modèles des risques proportionnels / Études rétrospectives / Facteurs de risque / Tumeurs épithéliales épidermoïdes et glandulaires / Estimation de Kaplan-Meier / Stadification tumorale Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2014 Type: Article