A Case of Epidermolysis Bullosa Acquisita Associated with Psoriasis / 대한피부과학회지
Korean Journal of Dermatology
; : 464-467, 2016.
Article
de Ko
| WPRIM
| ID: wpr-212268
Bibliothèque responsable:
WPRO
ABSTRACT
Epidermolysis bullosa acquisita (EBA) is an autoimmune subepidermal blistering disease characterized by the presence of circulating IgG autoantibodies to type VII collagen. Various types of autoimmune blistering disease have been reported in association with psoriasis. A 58-year-old man with a 5-year history of psoriasis vulgaris presented with painful and mildly pruritic erythematous multiple bullae and vesicles. Histopathologically, there was a subepidermal bulla with infiltration of inflammatory cells composed of neutrophils and eosinophils. The salt-split skin indirect immunofluorescence test showed IgG binding to the dermal side of the separation, and immunoblotting using normal human dermal extract revealed antibodies directed against a 290-kDa polypeptide. He was diagnosed with EBA and started medication of oral prednisolone and mycophenolate mofetil. Skin lesions were continuously regressed. Of all the autoimmune blistering diseases coexisting with psoriasis, bullous pemphigoid is the most frequent. However, a few cases of EBA associated with psoriasis have been reported in the literature. We report a rare case of EBA coexisting with psoriasis vulgaris.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Psoriasis
/
Peau
/
Autoanticorps
/
Immunoglobuline G
/
Prednisolone
/
Immunotransfert
/
Épidermolyse bulleuse acquise
/
Cloque
/
Épidermolyse bulleuse
/
Pemphigoïde bulleuse
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Dermatology
Année:
2016
Type:
Article