Effect of Tamsulosin HCl (0.2 mg) on Female Lower Urinary Tract Symptoms with Maximal Urinary Flow Rate Less Than 12 ml/sec
Korean Journal of Urology
;
: 130-134, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-212500
ABSTRACT
PURPOSE:
Alpha adrenergic components do not seem prevalent in the female bladder neck. Nevertheless, some studies using alpha-blockers in women suffering from obstructed urine flow have been reported. We assessed the effectiveness of administering an alpha 1-adrenoceptor antagonist, tamsulosin, in patients with a maximal flow rate less than 12 ml/sec. MATERIALS ANDMETHODS:
From January 2007 to December 2007, 150 patients with a maximal flow rate less than 12 ml/sec were selected for this study. Patients were treated with tamsulosin at a dose of 0.2 mg per day. The effectiveness of tamsulosin was assessed by analyzing the International Prostate Symptom Score (IPSS) and other parameters, including the maximal urinary flow rate (Qmax) and the amount of postvoid residual urine. The data for these parameters were acquired at baseline and after 4 and 12 weeks of treatment.RESULTS:
Of the 150 patients, 113 patients (75.3%) completed the study. Except for the storage symptom score, all clinical parameters, including total IPSS, voiding symptom score, Qmax, and the amount of residual urine, showed significant improvement after 4 and 12 weeks of treatment (p<0.05). The incidence of adverse events was only 4.4%, including dizziness in 3 patients, stress incontinence in 1 patient, and lethargy in 1 patient.CONCLUSIONS:
The alpha-1 adrenoceptor antagonist tamsulosin significantly improved subjective symptoms and uroflowmetric parameters in female patients with a low maximal flow rate of less than 12 ml/sec. The use of tamsulosin may be an initial treatment option in females with a low maximal urinary flow rate.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prostate
/
Stress psychologique
/
Sulfonamides
/
Vessie urinaire
/
Obstruction du col de la vessie
/
Incidence
/
Sensation vertigineuse
/
Léthargie
/
Symptômes de l'appareil urinaire inférieur
/
Cou
Type d'étude:
Etude diagnostique
/
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Urology
Année:
2009
Type:
Article
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