A case of carbamazepine-induced anticonvulsant hypersensitivity syndrome expressing eosinophilic pneumonia / 천식및알레르기

ABSTRACT

Anticonvulsant hypersensitivity syndrome is a potentially fatal drug reaction with cutaneous and systemic reactions to the arene oxide-producing anticonvulsants phenytoin, carbamazepine, and phenobarbital. In most cases, the hallmark features of fever, rash, and lymphadenopathy are accompanied by multiorgan-system abnormalities. We experienced a 41-year-old man with a carbamazepine-induced reaction, presenting with fever, rash, eosinophilia, hepatitis, and eosinophilic pneumonia. Because symptoms persisted in spite of discontinuation of carbamazepine, we administered a systemic steroid. After use of the steroid, symptoms were relieved and liver and pulmonary functions improved gradually.