Prevalence of aspirin sensitivity among asthmatic patients with mild to moderate severity and its clinical characteristics / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 100-108, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-213068
ABSTRACT
BACKGROUND:
While aspirin sensitivity has been known to be common among patients with severe asthma, its frequency among asthmatics with mild to moderate severity remains to be learned.OBJECTIVES:
To elucidate the frequency of aspirin sensitivity and its clinical characteristics among asthma patients with mild to moderate severity. MATERIAL ANDMETHODS:
A total of 96 asthmatics with mild to moderate severity were enrolled. They underwent lysine-aspirin and methacholine bronchial provocation tests, and gave their induced sputum after the lysine-aspirin challenge.RESULTS:
FEV1 declined greater than 20% compared with baseline FEV1 in 11 of 96 patients on the lysine-aspirin challenge. The frequency of aspirin sensitivity was higher among patients with enhanced bronchial hyperresponsiveness to methacholine (PC20 < 1 mg/ml) than among those without it (27.3% vs. 6.8%). The frequency was also higher in those with induced sputum eosinophil count higher than 3% than among those without it (38.9% vs. 0%). However, it was not associated with other risk factors such as age, sex, atopy, nasal polyps, and rhinosinusitis.CONCLUSION:
More than 10% of mild to moderate asthmatics have aspirin sensitivity even though they have experienced no history of aspirin sensitivity which may be related with bronchial hyperresponsiveness to methacholine and eosinophil activation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Expectoration
/
Tests de provocation bronchique
/
Acide acétylsalicylique
/
Polypes du nez
/
Prévalence
/
Facteurs de risque
/
Chlorure de méthacholine
/
Granulocytes éosinophiles
/
Asthme induit par l'aspirine
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of Asthma, Allergy and Clinical Immunology
Année:
2002
Type:
Article
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