Cord Blood Adiponectin and Insulin-like Growth Factor-I in Term Neonates of Gestational Diabetes Mellitus Mothers: Relationship to Fetal Growth
Journal of the Korean Society of Neonatology
;
: 49-58, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-213851
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM).METHODS:
Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data.RESULTS:
Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity.CONCLUSION:
Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Poids de naissance
/
Insulinorésistance
/
Facteur de croissance IGF-I
/
Âge gestationnel
/
Diabète gestationnel
/
Mensurations corporelles
/
Développement foetal
/
Adiponectine
/
Sang foetal
/
Hyperglycémie provoquée
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
langue:
Anglais
Texte intégral:
Journal of the Korean Society of Neonatology
Année:
2011
Type:
Article
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