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Long-term virological outcome in chronic hepatitis B patients with a partial virological response to entecavir
The Korean Journal of Internal Medicine ; : 170-176, 2015.
Article Dans Anglais | WPRIM | ID: wpr-214116
ABSTRACT
BACKGROUND/

AIMS:

The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-experienced chronic hepatitis B patients with a PVR to ETV.

METHODS:

Chronic hepatitis B patients treated with ETV (0.5 mg/day) for at least 1 year were enrolled retrospectively. PVR was defined as a decrease in hepatitis B virus (HBV) DNA titer of more than 2 log10 IU/mL, yet with residual serum HBV DNA, as determined by real time-polymerase chain reaction, at week 48 of ETV therapy.

RESULTS:

A total of 202 patients (127 NA-naive and 75 NA-experienced, male 70.8%, antigen positive 53.2%, baseline serum HBV DNA 6.2 +/- 1.5 log10 IU/mL) were analyzed. Twenty-eight patients demonstrated a PVR. The PVR was associated with a high serum HBV DNA titer at baseline and at week 24. Virological response (< 60 IU/mL) was achieved in 46.2%, 61.5%, 77.6%, and 85% of patients with PVR at week 72, 96, 144, and 192, respectively. Resistance to antivirals developed in two NA-experienced patients. Failure of virological response (VR) in patients with PVR was associated with high levels of serum HBV DNA at week 48.

CONCLUSIONS:

Patients with PVR to ETV had favorable long-term virological outcomes. The low serum level of HBV DNA (< 200 IU/mL) at week 48 was associated with subsequent development of a VR in patients with PVR to ETV.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Antiviraux / Facteurs temps / ADN viral / Marqueurs biologiques / Virus de l&apos;hépatite B / Études rétrospectives / Résultat thérapeutique / Charge virale / Hépatite B chronique / Résistance virale aux médicaments Type d'étude: Étude observationnelle Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Antiviraux / Facteurs temps / ADN viral / Marqueurs biologiques / Virus de l&apos;hépatite B / Études rétrospectives / Résultat thérapeutique / Charge virale / Hépatite B chronique / Résistance virale aux médicaments Type d'étude: Étude observationnelle Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2015 Type: Article