Hyperhomocysteinemia and Cerebrovascular Diseases in Koreans
Journal of the Korean Academy of Family Medicine
;
: 12-20, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-214352
ABSTRACT
BACKGROUND:
Hyperhomocysteinemia as a risk factor for cerebrovascular disease is well known. Our aim of this study was to demonstrate positive association between elevated homocysteine levels and cerebrovascular diseases in Koreans.METHODS:
With a case-control design, 186 stroke (infarction 134, hemorrhage 52) patients, diagnosed by brain CT or MRI and 359 control patients were evaluated. We used multiple logistic regression analyses conditioned on the matching variables (sex, age, hypertension, DM, smoking, hyperlipidemia, hyperhomocysteinemia) and calculated odds ratio and 95% CIs.RESULTS:
Multivariated adjusted odds ratios (OR) for cerebrovascular diseases associated with hypertension compared with normal blood pressure were 2.45 (95% CI, 1.16 to 5.15) in prehypertension and 3.33 (95% CI, 1.56 to 7.10) in stage 1 hypertension and 3.77 (95% CI, 1.32 to 10.74) in stage 2 hypertension. OR for cerebrovascular diseases associated with hyperhomocysteinemia compared with or =17 micromol/L.CONCLUSION:
Not only hypertension but also hyperhomocysteinemia was a significant risk factor for cerebrovascular diseases in Koreans.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Fumée
/
Pression sanguine
/
Encéphale
/
Imagerie par résonance magnétique
/
Fumer
/
Études cas-témoins
/
Modèles logistiques
/
Odds ratio
/
Facteurs de risque
/
Hyperhomocystéinémie
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Academy of Family Medicine
Année:
2006
Type:
Article
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