A Randomized, Open-Label, Multicenter Trial of Topical Tacrolimus for the Treatment of Pruritis in Patients with Atopic Dermatitis
Annals of Dermatology
;
: 144-150, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-214980
ABSTRACT
BACKGROUND:
Pruritis caused by atopic dermatitis (AD) is not always well controlled by topical corticosteroid therapy, but use of tacrolimus often helps to soothe such intractable pruritis in clinical settings.OBJECTIVE:
To determine the anti-pruritic efficacy of topical tacrolimus in treating AD in induction and maintenance therapy.METHODS:
Prior to the study, patients were randomly allocated into two groups, induction therapy followed by tacrolimus monotherapy maintenance, and induction therapy followed by emollient-only maintenance. In the induction therapy, the patients were allowed to use topical tacrolimus and emollients in addition to a low dose (<10 g/week) of topical steroids. Patients showing relief from pruritis were allowed to proceed to maintenance therapy. Recurrence of pruritis in maintenance therapy was examined as a major endpoint.RESULTS:
Two-thirds of patients (44/68; 64.7%) showed relief from pruritis after induction therapy. Pruritis recurred in 23.8% (5/21) of the tacrolimus monotherapy group and in 100% (21/21) of the emollient group during maintenance period, a difference that was statistically significant.CONCLUSION:
Use of topical tacrolimus is effective in controlling pruritis of AD compared to emollient.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prurit
/
Récidive
/
Stéroïdes
/
Tacrolimus
/
Eczéma atopique
/
Émollient
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Annals of Dermatology
Année:
2012
Type:
Article
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