A Clinical and Histopathological Study of 17 Cases of Cutaneous Pseudolymphoma / 대한피부과학회지

ABSTRACT

BACKGROUND: Although it is important to be aware of the clinicopathological features of pseudolymphoma of the skin to avoid misdiagnosis, there are few comprehensive studies on this disease entity in the Korean dermatologic literature. OBJECTIVE: The purpose of this study was to evaluate the clinical and histopathological features of pseudolymphoma. METHODS: We reviewed the medical records, photographs and histopathological slides of 17 patients, who had been diagnosed with cutaneous pseudolymphoma, between March 2001 and August 2011. RESULTS: The ratio of males to females was 13.3, and the mean age of onset was 47.8 years old. Ten patients (59%) had no symptom and the most commonly involved site was the head and neck (59%). Ten patients (59%) had a solitary lesion. Nobody had a family history or past history of pseudolymphoma or lymphoma. Of the 17 cases, 16 (94%) were idiopathic. The common microscopic feature of pseudolymphoma was diffuse and dense lymphocytic infiltration in the reticular dermis. In the immunohistochemical staining of 15 cases (88%), the infiltrating cells were positive for both B cell and T cell marker. The treatment included intralesional steroid injection, systemic steroids and excision. An average follow-up period was 38.4 months (from 2 to 107 months) for 13 patients. During this period, no recurrence or malignant transformation was observed in these patients. CONCLUSION: Our findings demonstrate that cutaneous pseudolymphoma is most common in middle-aged female, and it has a good response to steroid treatment or simple excision, without malignant transformation.