Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: Protein Expression, Gene Amplification and Survival Analysis
Korean Journal of Pathology
;
: 387-392, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-215312
ABSTRACT
BACKGROUND:
Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein expression and gene amplification, and the correlation between EGFR status and survival in NSCLC.METHODS:
We examined 360 cases of microarrayed NSCLC tissues for the EGFR protein expression and EGFR gene amplification using immunohistochemistry and fluorescent in situ hybridization.RESULTS:
EGFR protein expression and EGFR gene amplification occurred in 110 cases (30.6%) and 24 cases (6.7%), respectively. EGFR protein expression and gene amplification were more frequent in squamous cell carcinoma than in adenocarcinoma. Differences in EGFR protein expression did not dramatically affect survival curves (p=0.740), but differences in gene amplification did (p<0.05) EGFR gene amplification was associated with a lower 5-year survival rate.CONCLUSION:
EGFR protein expression and gene amplification showed moderate correlation with each other. EGFR gene amplification predicted a poor prognosis, whereas EGFR protein expression did not.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Immunohistochimie
/
Carcinome épidermoïde
/
Adénocarcinome
/
Expression des gènes
/
Analyse de survie
/
Amplification de gène
/
Taux de survie
/
Hybridation fluorescente in situ
/
Hybridation in situ
Type d'étude:
Étude pronostique
langue:
Coréen
Texte intégral:
Korean Journal of Pathology
Année:
2007
Type:
Article
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