Insulin Resistance and Insulin Resistance Syndrome / 한양의대학술지

ABSTRACT

Insulin resistance is the main pathophysiologic abnormality of type 2 diabetes mellitus. Insulin resistance and resultant compensatory hyperinsulinemia are closely associated with other important cardiovascular risk factors such as hypertension, dyslipidemia and artherosclerosis. Genetic factors and environmental factors such as obesity and physical inactivity contribute to the development of insulin resistance. Recently mitochondrial dysfunction, ER (endoplasmic Reticulum) stress and inflammation has been known to be linked with insulin resistance. At present, lifestyle modification and metformin and thiazolidinediones are known to reduce insulin resistance with some limitations. Considering both clinical importance of insulin resistance and rapid advances in our understanding of pathogenesis of insulin resistance, new therapeutic strategies based on novel molecular mechanisms of insulin resistance are anticipated