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Hepatitis B Surface Antigen Quantification across Different Phases of Chronic Hepatitis B Virus Infection Using an Immunoradiometric Assay
Gut and Liver ; : 657-664, 2015.
Article Dans Anglais | WPRIM | ID: wpr-216103
ABSTRACT
BACKGROUND/

AIMS:

Quantification of hepatitis B surface antigen (HBsAg) is an emerging serologic test and may be useful for identifying treatment strategies for chronic hepatitis B (CHB). This study aimed to evaluate HBsAg titers during the natural course of CHB and identify correlations between HBsAg titers and hepatitis B virus (HBV) DNA concentrations across different CHB phases measured using an immunoradiometric assay (IRMA).

METHODS:

CHB phases were defined on the basis of HBV DNA concentrations, the presence of hepatitis B e antigen/antibody (HBeAg/Ab) and serum alanine aminotransferase levels. Serum HBsAg titers and paired HBV DNA concentrations in the different phases of CHB were compared using 627 serum samples.

RESULTS:

Mean HBsAg titers were significantly higher in the immunotolerant (IT) phase and immunoreactive (IR) HBeAg-positive phase than in the low-replicative (LR) and HBeAg-negative CHB (ENH) states. The correlation between HBsAg titers and HBV DNA concentrations was modest in the IT (n=36, r=0.804, p<0.001) and IR (n=48, r=0.773, p<0.001) phases, and it was poor in the LR state (n=116, r=0.289, p=0.002); however, no significant correlation was observed in the ENH state (n=67, r=0.146, p=0.237) or in the oral nucleos(t)ide analogue-treated group (n=267).

CONCLUSIONS:

HBsAg quantification using IRMA might be useful for discriminating different CHB phases and different stages of chronic liver disease.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Réplication virale / ADN viral / Marqueurs biologiques / Dosage radioimmunométrique / Virus de l&apos;hépatite B / Évolution de la maladie / Charge virale / Hépatite B chronique / Alanine transaminase / Séoul Limites du sujet: Adulte / Femelle / Humains / Mâle Pays comme sujet: Asie langue: Anglais Texte intégral: Gut and Liver Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Réplication virale / ADN viral / Marqueurs biologiques / Dosage radioimmunométrique / Virus de l&apos;hépatite B / Évolution de la maladie / Charge virale / Hépatite B chronique / Alanine transaminase / Séoul Limites du sujet: Adulte / Femelle / Humains / Mâle Pays comme sujet: Asie langue: Anglais Texte intégral: Gut and Liver Année: 2015 Type: Article