The Expression of Toll-like Receptors in Idiopathic Inflammatory Myopathies / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 118-124, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-216856
ABSTRACT
Objective:
To investigate the expression of toll-like receptor (TLR)-2, 4 and 9 in idiopathic inflammatory myopathies (IIMs).Methods:
The expression of TLR-2, 4 and 9 was measured by real-time RT-PCR and immunohistochemical stain (IHS) from muscle tissues in patients with IIMs and controls.Results:
The expression levels of TLR-2, 4 and 9 in IIMs were significantly higher than controls. TLR-2, 4 and 9 were mainly expressed on sarcolemma of muscle fibers, perimysial vascular endothelium and infiltrating inflammatory cells in dermatomyositis, whereas, they were mainly expressed on sarcolemma of muscle fibers, destructed muscle fibers, and enodmysial infiltrating inflammatory cells in polymyositis.Conclusion:
TLR-2, 4 and 9 were highly expressed in muscle tissue of IIMs. These results suggest that TLR-2, 4 and 9 play a role in pathogenesis of IIMs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sarcolemme
/
Endothélium vasculaire
/
Polymyosite
/
Dermatomyosite
/
Récepteurs de type Toll
/
Myosite
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
The Journal of the Korean Rheumatism Association
Année:
2007
Type:
Article
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