Thrombophilia in Korean patients with arterial or venous thromboembolisms
Annals of Surgical Treatment and Research
;
: 340-345, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-217439
ABSTRACT
PURPOSE:
To determine the prevalence of thrombophilia in Korean patients with an arterial thromboembolism (ATE) or a venous thromboembolism (VTE), and to evaluate the characteristic of VTE in patients with thrombophilia.METHODS:
Hospital records of 294 patients (228 with VTE, 66 with ATE) including two foreign ones (mean age, 51.4 years) who underwent thrombophilia testing between August 2006 and March 2015 were reviewed retrospectively. In general, such screening was performed according to the guidelines of the international consensus statement for VTE. Thrombophilia testing included evaluations of the factor V Leiden and prothrombin G20210A mutations, levels of proteins C and S and antithrombin, and antiphospholipid antibody syndrome (APLS).RESULTS:
A factor V Leiden mutation was not found in the 292 Korean patients. A prothrombin G21210A mutation was investigated in 33 patients but none was found. Among 226 Korean patients with VTE, 130 demonstrated no thrombophilia and 55 patients did after exclusion of 41 patients without confirmatory test. The most common form was protein S deficiency (31 of 55, 56%) followed by protein C deficiency, antithrombin deficiency, and APLS. When comparing patients with a VTE or deep vein thrombosis (DVT) according to the presence of thrombophilia, thrombophilia was associated with younger age (P = 0.001 for VTE; P < 0.001 for DVT) and a family history (P < 0.001 for VTE and DVT).CONCLUSION:
We did not find any factor V Leiden mutation in Korean subjects at high risk for thrombophilia. Therefore, this testing is not warranted. Thrombophilia was associated with VTE in younger age and a family history.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thromboembolie
/
Proaccélérine
/
Prothrombine
/
Archives administratives hospitalières
/
Dépistage de masse
/
Prévalence
/
Études rétrospectives
/
Syndrome des anticorps antiphospholipides
/
Déficit en protéine S
/
Thrombophilie
Type d'étude:
Guide de pratique
/
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Annals of Surgical Treatment and Research
Année:
2016
Type:
Article
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