Impact of Postoperative Oral Administration of UFT for Completely Resected pT2N0 Non-Small Cell Lung Cancer / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 428-434, 2007.
Article
de Ko
| WPRIM
| ID: wpr-218385
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: Recent studies have suggested that UFT may be an effective adjuvant therapy for completely resected IB (pT2N0) non-small cell lung cancer (NSCLC). We designed this study to clarify the feasibility of performing adjuvant chemotherapy with UFT for completely resected IB non-small cell lung cancer. MATERIAL AND METHOD: We randomly assigned patients suffering with completely resected IB non-small cell lung cancer to receive either UFT 3g for 2 year or they received no treatment. All patients had to be followed until death or the cut-off date (December 31 2006). RESULT: From June 2002 through December 2004, 64 patients were enrolled. Thirty five patients were assigned to receive UFT(the UFT group) and 29 patients were assigned to observation (the control group). A follow-up survey on the 3 year survival rate was successfully completed for all the patients. The median follow-up time for all the patients was 32.8 months. In the UFT group, the median time of administration was 98 weeks (range: 2~129 weeks). The rate of compliance was 88.2% at 6 months, 87.5% at 12 months, 80.6% at 18 month and 66.7% at 24 months. Seven recurrences (24.1%) occurred in the control group and six (17.1%) occurred in the UFT group (p=0.489). The three-year disease free survival rate was 71.3% for the control group and 82.0% for the UFT group (p=0.331). On the subgroup analysis, the three-year disease free survival rate for the patients with adenocacinoma was 45.0% for the control group and 75.2% for the UFT group (p=0.121). The three-year disease free survival rate for the patients with non-adenocarcinoma was 88.1% for the control group and 88.9% for the UFT group (p=0.964). CONCLUSION: Postoperative oral administration of UFT was well-tolerated. Adjuvant chemotherapy with UFT for completely resected pT2N0 adenocarcinoma of the lung could be expected to improve the disease free survival, but this failed to achieve statistical significance. A prospective randomized study for a large number of patients will be necessary.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Récidive
/
Adénocarcinome
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Administration par voie orale
/
Taux de survie
/
Études de suivi
/
Traitement médicamenteux adjuvant
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Carcinome pulmonaire non à petites cellules
/
Compliance
/
Survie sans rechute
/
Poumon
Type d'étude:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
The Korean Journal of Thoracic and Cardiovascular Surgery
Année:
2007
Type:
Article