Effects of Metabolic Syndrome on Chronic Kidney Disease
Korean Journal of Urology
;
: 261-266, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-218434
ABSTRACT
PURPOSE:
Metabolic syndrome (MS) has been identified as a causal risk factor for cardiovascular disease, stroke, and cardiovascular mortality. Recent studies have suggested a possible relation between MS and renal function. The aim of this study was to evaluate the influence of MS on renal function. MATERIALS ANDMETHODS:
We analyzed 12,348 healthy Koreans who underwent a general health checkup. MS was defined as 3 or more of the criteria according to the National Cholesterol Education Program Adult Treatment Panel guidelines III (NCEP ATP III). The glomerular filtration rate (GFR) was estimated by the redefined Modification of Diet in Renal Disease formula. Chronic kidney disease (CKD) was categorized into 3 categories according to the Kidney Disease Improving Global Outcomes guidelines; I GFR> or =90 ml/min, II 60-89 ml/min, III 30-59 ml/min.RESULTS:
The overall proportion with MS was 19.3%. Compared with populations without MS, those with MS showed a significantly decreased GFR. The prevalence of CKD increased with the number of MS components, and it was prominent in the group of males over 40 years of age. In multivariate analyses using age, sex, and individual MS components, age (odds ratio [OR]=20.40; 95% CI 10.81-38.49), sex (OR=1.98; 95% CI 1.51-2.60), and obesity (OR=1.48; 95% CI 1.13-1.93) were strongly associated with CKD.CONCLUSIONS:
This study showed that MS is a significant determinant of CKD. Handling of correctable factors such as obesity may be considered one of the preventive modalities against the development of CKD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladies cardiovasculaires
/
Adénosine triphosphate
/
Cholestérol
/
Prévalence
/
Analyse multifactorielle
/
Facteurs de risque
/
Accident vasculaire cérébral
/
Régime alimentaire
/
Insuffisance rénale chronique
/
Débit de filtration glomérulaire
Type d'étude:
Etude d'étiologie
/
Guide de pratique
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Korean Journal of Urology
Année:
2009
Type:
Article
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